Cannabis ingredient holds promise as antipsychotic medicine

Reuters / By Kate Kelland /  December 15, 2017

LONDON (Reuters) – An ingredient in cannabis called cannabidiol or CBD has shown promise in a clinical trial as a potential new treatment for psychosis, scientists said on Friday.

Scientists conducted a small trial of people with psychosis and found patients treated with CBD had lower levels of psychotic symptoms than those who received a placebo. Psychosis is characterized by paranoia and hallucinations.

The study found that they were also more likely to be rated as “improved” by their psychiatrist and there were signs of better cognitive performance and functioning.

The main psychoactive ingredient in cannabis is delta-9-tetrahydrocannabinol, or THC. It can induce paranoia and anxiety and hallucinations and has been found in studies to increase the risk psychotic illness in people who regularly use potent forms of cannabis such as skunk.

But its second major constituent, CBD, has the opposite effects to THC – leading scientists to think it might one day be useful as a treatment in mental health.

Scientists at King’s College London’s Institute of Psychiatry, Psychology & Neuroscience conducted a placebo-controlled trial of CBD in patients with psychosis and published their findings in the American Journal of Psychiatry.

In the trial, 88 patients with psychosis received either CBD or placebo for six weeks, alongside their existing antipsychotic medication. Beforehand and afterwards, the scientists assessed symptoms, functioning and cognitive performance, and the patients’ psychiatrists rated their overall condition overall.

He noted that trial patients also reported few adverse side effects, and added: “Although it is still unclear exactly how CBD works, it acts in a different way to antipsychotic medication, and .. could represent a new class of treatment.”